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Drug testing using animals animals became important in the twentieth century. In 1937, a pharmaceutical company in the USA created a preparation of sulfanilamide, using diethylene glycol (DEG) as a solvent, and called the preparation Elixir Sulfanilamide'. DEG was poisonous to humans, but the company's chief pharmacist and chemist was not aware of this. He simply added raspberry flavoring to the sulfa drug, which he had dissolved in DEG, and the company marketed the product. The preparation led to mass poisoning causing the deaths of more than a hundred people. No animal testing was done. The public outcry caused by this incident and other similar disasters led to the passing of the 1938 Federal Food, Drug, and Cosmetic Act requiring safety testing of drugs on animals before they could be marketed.
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